May 27, 2025
— 6 min read
May 27, 2025
— 6 min read
May 27, 2025
— 6 min read
From Insight to Action:
Turning Health Data Into a Longevity Plan
From Insight to Action: Turning Health Data Into a Longevity Plan
From Insight to Action:
Turning Health Data Into a Longevity Plan
More health data doesn’t guarantee better health. At Biograph, we turn diagnostics into action, using personalized strategies to lower chronic disease risk and improve quality of life.
More health data doesn’t guarantee better health. At Biograph, we turn diagnostics into action, using personalized strategies to lower chronic disease risk and improve quality of life.
More health data doesn’t guarantee better health. At Biograph, we turn diagnostics into action, using personalized strategies to lower chronic disease risk and improve quality of life.
Michael Doney
Executive Medical Director
Michael Doney
Executive Medical Director
Michael Doney
Executive Medical Director
It’s Not Just About More Data
We are living in the golden age of personal health data. Today’s health-conscious individual can access more information than ever before, including blood biomarkers, full-body MRI scans, VO₂ max testing, wearable sleep trackers, genetic testing, microbiome sequencing, and epigenetic clocks.
But not all data is created equal. More numbers don’t automatically deliver better insights or better health. What matters is whether the data you collect leads to actionable guidance that improves long-term outcomes.
At Biograph, we focus on selecting the right diagnostics — the ones that go beyond surface measurements to uncover deeper, more actionable insights. But even the best data is only the beginning. Without expert interpretation and a clear plan, data can quickly become overwhelming or even misleading.
How Biograph Transforms Data Into a Personalized Plan
Most self-serve diagnostics offer numerical results but little in the way of interpretation or prioritization. A slightly high LDL, borderline low testosterone, or an elevated inflammation marker can all prompt confusion or anxiety when presented in isolation. But true insight comes from connecting the dots across systems.
30+
Exams in a single day for Black tier members
1,000+
Data points analyzed to generate your personalized risk and health profile
Biograph’s clinical model begins with deep diagnostics, generating over 1,000 data points from 20+ evaluations in the Core tier and 30+ in the Black tier. These assessments include blood panels, full-body MRI, VO2 max testing, DEXA scans, and more. The results are synthesized into a multidomain risk profile that integrates both chronic disease indicators and quality of life metrics.
Our clinical team organizes your results into five primary areas: cardiovascular disease, metabolic dysfunction, neurodegenerative disease, cancer risk, and quality-of-life indicators such as sleep quality, resilience, and functional fitness. From there, we review your complete health picture with you in one-on-one consultations, helping you prioritize the areas that matter most and translate insights into a personalized action plan. This approach ensures that every recommendation is grounded in clinical evidence and tailored to your goals, preferences, and capacity for change.
CASE STUDY
Making Health Data Actionable
A mid-40s Biograph member with a strong family history of cardiovascular disease came in for a comprehensive evaluation. On the surface, he appeared in excellent shape, with high cardiorespiratory fitness and above-average lean mass.
But deeper testing told a more complex story. Body composition scans revealed elevated visceral fat mass and a high fat mass index, both hidden markers of metabolic risk. Bloodwork showed fasting hyperglycemia, insulin resistance, and elevated LDL cholesterol and ApoB levels. Sleep assessments uncovered poor sleep quality, adding another layer of stress to his system.
Biograph’s multidisciplinary team provided targeted exercise and nutrition guidance to improve metabolic flexibility and reduce cardiovascular risk.
Exercise recommendations included Zone 2 aerobic training, resistance and stability work, and a structured weekly distribution of cardio zones.
Nutrition guidance focused on total daily calories, strategic food substitutions, meal timing, and defined targets for fiber, protein, and saturated fat.
After six months, follow-up assessments showed:
A 20-pound reduction in weight
A 20-30% reduction in LDL cholesterol, ApoB, and fasting insulin
Preserved lean muscle mass and marked improvements in total body fat index and visceral fat mass
Noticeably improved sleep quality
With the right diagnostic insights, targeted interventions like exercise and nutrition can dramatically reduce risks and transform long-term health outcomes – even in individuals who appear outwardly fit.
Five Key Tactics That Turn Data Into Health Outcomes
Data only becomes valuable when it leads to action. At Biograph, we structure personalized prevention and health optimization around five tactics.
Exercise
Nutrition
Sleep
Mental Health
Medications and Supplements
These domains are interdependent. Improving one often enhances the others. For example, better sleep can improve insulin sensitivity. Increased muscle mass can improve glucose disposal. Reduced inflammation can improve mood and cognitive performance.
Let’s look at how data informs each domain, and how targeted interventions create compounding benefits over time.
Exercise: Optimizing Strength, Stability, and Cardiorespiratory Fitness
Exercise is one of the most powerful tools in preventive medicine. At Biograph, we approach it through four pillars that support long-term health: Strength, Stability, Aerobic Capacity, and Metabolic Flexibility.
For every member, we assess baseline performance — using VO₂ max testing, grip strength, body composition, movement analysis, and a review of current exercise routines and goals — and design personalized recommendations to target the right mix of these pillars.
Strength: Resistance training can enhance insulin sensitivity, support joint health, and lower the risk of falls and frailty. Research shows that higher muscle mass and increased muscular strength are each independently associated with significantly lower all-cause mortality.
Stability: Addressing asymmetries and movement deficits increases movement efficiency, reduces injury risk, and supports overall physical performance.
Maximum Aerobic Capacity: VO₂ max, the gold standard for cardiorespiratory fitness, is a powerful predictor of long-term health. One major study found that individuals with elite cardiorespiratory fitness levels had up to a fivefold lower risk of all-cause mortality compared to those with low fitness.
Metabolic Flexibility: This reflects how efficiently the body uses fat as fuel at lower intensities. Properly integrating and balancing Zone 2 training with higher intensity exercise boosts fat oxidation and improves mitochondrial function — key for managing insulin resistance and enhancing recovery.
Together, improvements across these four areas enhance cardiovascular efficiency, metabolic control, and neuromuscular resilience. More importantly, they help preserve performance, autonomy, and quality of life into later decades.
Nutrition: Personalization Over Fads
Nutrition is foundational to metabolic and cardiovascular health, yet most public advice remains generalized. Studies have shown that individual responses to diet vary widely, underscoring the need for a personalized approach based on measurable biomarkers.
At Biograph, dietary planning is shaped by objective data. Comprehensive labs measure insulin sensitivity, lipid profiles, liver enzymes, micronutrient levels, and inflammatory markers. DEXA scans assess fat distribution and lean mass — critical factors influencing metabolic health and disease risk.
We also gather key personal inputs: eating patterns, nutrition goals, and any past challenges. These insights help ensure recommendations are not just biologically appropriate but also realistic and sustainable.
Biograph’s approach goes beyond generic dietary advice by aligning each member’s biology and behaviors with practical, evidence-based nutrition strategies. Depending on individual needs, this might mean a low-glycemic, high-fiber diet for elevated fasting insulin and low HDL cholesterol, increased protein intake to prevent sarcopenia, or targeted supplementation for vitamin deficiencies. We have also seen members successfully apply behavioral levers such as adjusting what they eat, how much they eat, or when they eat to reinforce these biological strategies and improve adherence.
Nutrition is not about following generalized rules. It is about applying the right strategies, tailored to each individual’s biology and needs, to drive real, lasting improvements.
Sleep and Mental Health: Essential Drivers of Long-Term Health
Sleep is one of the most underestimated pillars of health. Yet poor sleep quality is linked to increased risk of hypertension, obesity, insulin resistance, cognitive decline, and even cancer. Meta-analyses have confirmed that both short and disrupted sleep significantly increase the risk of all-cause mortality.
At Biograph, we assess sleep using validated surveys and at-home wearables that can detect disorders such as sleep apnea. If sleep apnea is identified, members are referred to our specialized sleep expert partners for additional consultation. Insomnia may benefit from referral for cognitive behavioral therapy for sleep, stress reduction protocols, and supplement support like magnesium, glycine, or melatonin under clinician guidance.
In parallel, we assess psychological resilience through validated tools that screen for depression and anxiety. Mental health is deeply interconnected with both sleep quality and long-term cardiovascular function. One large study found that depression is associated with a 52% increase in relative risk of all-cause mortality in older adults; another study found that chronic stress is associated with telomere shortening and accelerated biological aging.
At Biograph, these insights help identify opportunities for intervention and guide care planning across both psychological and physiological domains. We incorporate targeted support, including referrals for therapy, lifestyle counseling, and strategies that strengthen resilience, enhance cardiovascular and cognitive function, and sustain long-term vitality.
Medications and Supplements: Use Them When They Add Value
When risk is high or lifestyle change is not enough, medications and supplements can provide additional leverage. But the key is personalization.
For example, if a CT coronary angiography shows atherosclerosis, lipid-lowering therapy in combination with lifestyle intervention may be warranted. In randomized trials, statins have been shown to reduce major cardiac events by up to 20 percent in primary prevention populations. If insulin resistance is present, metformin is often considered in conjunction with lifestyle interventions. Beyond its role in improving metabolic health, metformin is being studied in the landmark TAME trial for its potential to modify age-related disease risk.
Supplement recommendations are similarly guided by diagnostics, targeting only confirmed deficiencies or therapeutic gaps, such as:
Vitamin D for low serum levels, especially in the context of bone or immune health
Vitamin B12 to address elevated serum homocysteine and long-term brain health
Omega-3s for high triglycerides or systemic inflammation
Magnesium to support muscle recovery and sleep quality
The goal is not to pile on supplements, but instead to strategically use interventions with proven benefit, guided by individualized data.
Conclusion: The Future of Preventive Health Is Personalized, Integrated, and Data-Driven
The future of prevention is not one-size-fits-all. It is personal, precise, and built to evolve. At Biograph, we turn diagnostics into action by creating data-informed strategies tailored to the individual, guided by experts, and measured by meaningful outcomes. This is not theoretical — we witness every day how personalized, data-driven plans drive meaningful, lasting improvements in health and longevity.
Turn Data Into Action
See how Biograph translates diagnostics into personalized, data-driven plans to extend your healthspan.
Written by Michael Doney
Executive Medical Director
Dr. Doney is Biograph’s Executive Medical Director, overseeing our entire clinical team. Prior to joining Biograph, he served as Director of Medical Affairs at Human Longevity and Group42 Healthcare, and spent 4 years at the US CDC as an Associate Division Director. He received his medical degree from the University of Cincinnati and completed his residency in emergency medicine at UC San Diego.
References
Schillaci O, Spanu A, Filippi L, et al. Single photon emission computed tomography/computed tomography in abdominal diseases. Semin Nucl Med. 2009;39(2):113-128. doi:10.1053/j.semnuclmed.2008.09.004
Brodersen J, Thorsen H, Kreiner S, et al. Consequences of screening in breast cancer (COS-BC): development of a questionnaire. BMJ. 2008;337:a439. https://www.bmj.com/content/337/bmj.a439
Reuland DS, Cubillos L, Brenner AT, et al. A pre-post study testing a lung cancer screening decision aid in primary care. JAMA Netw Open. 2018;1(3):e180575. doi:10.1001/jamanetworkopen.2018.0575
Garcia-Tsao G, Lim JK, Lim YS, et al. AASLD clinical practice guidance on the clinical assessment and management of portal hypertension. Am J Gastroenterol. 2022;117(10):1526-1557. doi:10.14309/ajg.0000000000002073
Jha S, Topol EJ. Adapting to artificial intelligence: radiologists and pathologists as information specialists. JAMA. 2016;316(22):2353-2354. doi:10.1001/jama.2016.17438
Dwamena BA, Gifford E, Holleman DR, et al. Likelihood ratios. JAMA. 2012;308(13):1377-1378. doi:10.1001/jama.2012.28357
Esserman LJ, Shieh Y, Thompson I. Rethinking screening for breast cancer and prostate cancer. JAMA. 2009;302(15):1685-1692. doi:10.1001/jama.2009.1498
Slovic P, Peters E, Finucane ML, MacGregor DG. Affect, risk, and decision making. Proc Natl Acad Sci USA. 2005;102(Suppl 2):3772-3776. doi:10.1073/pnas.0407162101
Welch HG, Schwartz LM, Woloshin S. Overdiagnosed: making people sick in the pursuit of health. N Engl J Med. 2008;358(24):2633-2635. doi:10.1056/NEJMoa0807646
Pate A, Martensson J, Elm E. Informed decision-making about cancer screening. BMC Med Inform Decis Mak. 2018;18(1):100. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943638/
It’s Not Just About More Data
We are living in the golden age of personal health data. Today’s health-conscious individual can access more information than ever before, including blood biomarkers, full-body MRI scans, VO₂ max testing, wearable sleep trackers, genetic testing, microbiome sequencing, and epigenetic clocks.
But not all data is created equal. More numbers don’t automatically deliver better insights or better health. What matters is whether the data you collect leads to actionable guidance that improves long-term outcomes.
At Biograph, we focus on selecting the right diagnostics — the ones that go beyond surface measurements to uncover deeper, more actionable insights. But even the best data is only the beginning. Without expert interpretation and a clear plan, data can quickly become overwhelming or even misleading.
How Biograph Transforms Data Into a Personalized Plan
Most self-serve diagnostics offer numerical results but little in the way of interpretation or prioritization. A slightly high LDL, borderline low testosterone, or an elevated inflammation marker can all prompt confusion or anxiety when presented in isolation. But true insight comes from connecting the dots across systems.
30+
Exams in a single day for Black tier members
1,000+
Data points analyzed to generate your personalized risk and health profile
Biograph’s clinical model begins with deep diagnostics, generating over 1,000 data points from 20+ evaluations in the Core tier and 30+ in the Black tier. These assessments include blood panels, full-body MRI, VO2 max testing, DEXA scans, and more. The results are synthesized into a multidomain risk profile that integrates both chronic disease indicators and quality of life metrics.
Our clinical team organizes your results into five primary areas: cardiovascular disease, metabolic dysfunction, neurodegenerative disease, cancer risk, and quality-of-life indicators such as sleep quality, resilience, and functional fitness. From there, we review your complete health picture with you in one-on-one consultations, helping you prioritize the areas that matter most and translate insights into a personalized action plan. This approach ensures that every recommendation is grounded in clinical evidence and tailored to your goals, preferences, and capacity for change.
CASE STUDY
Making Health Data Actionable
A mid-40s Biograph member with a strong family history of cardiovascular disease came in for a comprehensive evaluation. On the surface, he appeared in excellent shape, with high cardiorespiratory fitness and above-average lean mass.
But deeper testing told a more complex story. Body composition scans revealed elevated visceral fat mass and a high fat mass index, both hidden markers of metabolic risk. Bloodwork showed fasting hyperglycemia, insulin resistance, and elevated LDL cholesterol and ApoB levels. Sleep assessments uncovered poor sleep quality, adding another layer of stress to his system.
Biograph’s multidisciplinary team provided targeted exercise and nutrition guidance to improve metabolic flexibility and reduce cardiovascular risk.
Exercise recommendations included Zone 2 aerobic training, resistance and stability work, and a structured weekly distribution of cardio zones.
Nutrition guidance focused on total daily calories, strategic food substitutions, meal timing, and defined targets for fiber, protein, and saturated fat.
After six months, follow-up assessments showed:
A 20-pound reduction in weight
A 20-30% reduction in LDL cholesterol, ApoB, and fasting insulin
Preserved lean muscle mass and marked improvements in total body fat index and visceral fat mass
Noticeably improved sleep quality
With the right diagnostic insights, targeted interventions like exercise and nutrition can dramatically reduce risks and transform long-term health outcomes – even in individuals who appear outwardly fit.
Five Key Tactics That Turn Data Into Health Outcomes
Data only becomes valuable when it leads to action. At Biograph, we structure personalized prevention and health optimization around five tactics.
Exercise
Nutrition
Sleep
Mental Health
Medications and Supplements
These domains are interdependent. Improving one often enhances the others. For example, better sleep can improve insulin sensitivity. Increased muscle mass can improve glucose disposal. Reduced inflammation can improve mood and cognitive performance.
Let’s look at how data informs each domain, and how targeted interventions create compounding benefits over time.
Exercise: Optimizing Strength, Stability, and Cardiorespiratory Fitness
Exercise is one of the most powerful tools in preventive medicine. At Biograph, we approach it through four pillars that support long-term health: Strength, Stability, Aerobic Capacity, and Metabolic Flexibility.
For every member, we assess baseline performance — using VO₂ max testing, grip strength, body composition, movement analysis, and a review of current exercise routines and goals — and design personalized recommendations to target the right mix of these pillars.
Strength: Resistance training can enhance insulin sensitivity, support joint health, and lower the risk of falls and frailty. Research shows that higher muscle mass and increased muscular strength are each independently associated with significantly lower all-cause mortality.
Stability: Addressing asymmetries and movement deficits increases movement efficiency, reduces injury risk, and supports overall physical performance.
Maximum Aerobic Capacity: VO₂ max, the gold standard for cardiorespiratory fitness, is a powerful predictor of long-term health. One major study found that individuals with elite cardiorespiratory fitness levels had up to a fivefold lower risk of all-cause mortality compared to those with low fitness.
Metabolic Flexibility: This reflects how efficiently the body uses fat as fuel at lower intensities. Properly integrating and balancing Zone 2 training with higher intensity exercise boosts fat oxidation and improves mitochondrial function — key for managing insulin resistance and enhancing recovery.
Together, improvements across these four areas enhance cardiovascular efficiency, metabolic control, and neuromuscular resilience. More importantly, they help preserve performance, autonomy, and quality of life into later decades.
Nutrition: Personalization Over Fads
Nutrition is foundational to metabolic and cardiovascular health, yet most public advice remains generalized. Studies have shown that individual responses to diet vary widely, underscoring the need for a personalized approach based on measurable biomarkers.
At Biograph, dietary planning is shaped by objective data. Comprehensive labs measure insulin sensitivity, lipid profiles, liver enzymes, micronutrient levels, and inflammatory markers. DEXA scans assess fat distribution and lean mass — critical factors influencing metabolic health and disease risk.
We also gather key personal inputs: eating patterns, nutrition goals, and any past challenges. These insights help ensure recommendations are not just biologically appropriate but also realistic and sustainable.
Biograph’s approach goes beyond generic dietary advice by aligning each member’s biology and behaviors with practical, evidence-based nutrition strategies. Depending on individual needs, this might mean a low-glycemic, high-fiber diet for elevated fasting insulin and low HDL cholesterol, increased protein intake to prevent sarcopenia, or targeted supplementation for vitamin deficiencies. We have also seen members successfully apply behavioral levers such as adjusting what they eat, how much they eat, or when they eat to reinforce these biological strategies and improve adherence.
Nutrition is not about following generalized rules. It is about applying the right strategies, tailored to each individual’s biology and needs, to drive real, lasting improvements.
Sleep and Mental Health: Essential Drivers of Long-Term Health
Sleep is one of the most underestimated pillars of health. Yet poor sleep quality is linked to increased risk of hypertension, obesity, insulin resistance, cognitive decline, and even cancer. Meta-analyses have confirmed that both short and disrupted sleep significantly increase the risk of all-cause mortality.
At Biograph, we assess sleep using validated surveys and at-home wearables that can detect disorders such as sleep apnea. If sleep apnea is identified, members are referred to our specialized sleep expert partners for additional consultation. Insomnia may benefit from referral for cognitive behavioral therapy for sleep, stress reduction protocols, and supplement support like magnesium, glycine, or melatonin under clinician guidance.
In parallel, we assess psychological resilience through validated tools that screen for depression and anxiety. Mental health is deeply interconnected with both sleep quality and long-term cardiovascular function. One large study found that depression is associated with a 52% increase in relative risk of all-cause mortality in older adults; another study found that chronic stress is associated with telomere shortening and accelerated biological aging.
At Biograph, these insights help identify opportunities for intervention and guide care planning across both psychological and physiological domains. We incorporate targeted support, including referrals for therapy, lifestyle counseling, and strategies that strengthen resilience, enhance cardiovascular and cognitive function, and sustain long-term vitality.
Medications and Supplements: Use Them When They Add Value
When risk is high or lifestyle change is not enough, medications and supplements can provide additional leverage. But the key is personalization.
For example, if a CT coronary angiography shows atherosclerosis, lipid-lowering therapy in combination with lifestyle intervention may be warranted. In randomized trials, statins have been shown to reduce major cardiac events by up to 20 percent in primary prevention populations. If insulin resistance is present, metformin is often considered in conjunction with lifestyle interventions. Beyond its role in improving metabolic health, metformin is being studied in the landmark TAME trial for its potential to modify age-related disease risk.
Supplement recommendations are similarly guided by diagnostics, targeting only confirmed deficiencies or therapeutic gaps, such as:
Vitamin D for low serum levels, especially in the context of bone or immune health
Vitamin B12 to address elevated serum homocysteine and long-term brain health
Omega-3s for high triglycerides or systemic inflammation
Magnesium to support muscle recovery and sleep quality
The goal is not to pile on supplements, but instead to strategically use interventions with proven benefit, guided by individualized data.
Conclusion: The Future of Preventive Health Is Personalized, Integrated, and Data-Driven
The future of prevention is not one-size-fits-all. It is personal, precise, and built to evolve. At Biograph, we turn diagnostics into action by creating data-informed strategies tailored to the individual, guided by experts, and measured by meaningful outcomes. This is not theoretical — we witness every day how personalized, data-driven plans drive meaningful, lasting improvements in health and longevity.
Turn Data Into Action
See how Biograph translates diagnostics into personalized, data-driven plans to extend your healthspan.
Written by Michael Doney
Executive Medical Director
Dr. Doney is Biograph’s Executive Medical Director, overseeing our entire clinical team. Prior to joining Biograph, he served as Director of Medical Affairs at Human Longevity and Group42 Healthcare, and spent 4 years at the US CDC as an Associate Division Director. He received his medical degree from the University of Cincinnati and completed his residency in emergency medicine at UC San Diego.
References
Schillaci O, Spanu A, Filippi L, et al. Single photon emission computed tomography/computed tomography in abdominal diseases. Semin Nucl Med. 2009;39(2):113-128. doi:10.1053/j.semnuclmed.2008.09.004
Brodersen J, Thorsen H, Kreiner S, et al. Consequences of screening in breast cancer (COS-BC): development of a questionnaire. BMJ. 2008;337:a439. https://www.bmj.com/content/337/bmj.a439
Reuland DS, Cubillos L, Brenner AT, et al. A pre-post study testing a lung cancer screening decision aid in primary care. JAMA Netw Open. 2018;1(3):e180575. doi:10.1001/jamanetworkopen.2018.0575
Garcia-Tsao G, Lim JK, Lim YS, et al. AASLD clinical practice guidance on the clinical assessment and management of portal hypertension. Am J Gastroenterol. 2022;117(10):1526-1557. doi:10.14309/ajg.0000000000002073
Jha S, Topol EJ. Adapting to artificial intelligence: radiologists and pathologists as information specialists. JAMA. 2016;316(22):2353-2354. doi:10.1001/jama.2016.17438
Dwamena BA, Gifford E, Holleman DR, et al. Likelihood ratios. JAMA. 2012;308(13):1377-1378. doi:10.1001/jama.2012.28357
Esserman LJ, Shieh Y, Thompson I. Rethinking screening for breast cancer and prostate cancer. JAMA. 2009;302(15):1685-1692. doi:10.1001/jama.2009.1498
Slovic P, Peters E, Finucane ML, MacGregor DG. Affect, risk, and decision making. Proc Natl Acad Sci USA. 2005;102(Suppl 2):3772-3776. doi:10.1073/pnas.0407162101
Welch HG, Schwartz LM, Woloshin S. Overdiagnosed: making people sick in the pursuit of health. N Engl J Med. 2008;358(24):2633-2635. doi:10.1056/NEJMoa0807646
Pate A, Martensson J, Elm E. Informed decision-making about cancer screening. BMC Med Inform Decis Mak. 2018;18(1):100. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943638/
It’s Not Just About More Data
We are living in the golden age of personal health data. Today’s health-conscious individual can access more information than ever before, including blood biomarkers, full-body MRI scans, VO₂ max testing, wearable sleep trackers, genetic testing, microbiome sequencing, and epigenetic clocks.
But not all data is created equal. More numbers don’t automatically deliver better insights or better health. What matters is whether the data you collect leads to actionable guidance that improves long-term outcomes.
At Biograph, we focus on selecting the right diagnostics — the ones that go beyond surface measurements to uncover deeper, more actionable insights. But even the best data is only the beginning. Without expert interpretation and a clear plan, data can quickly become overwhelming or even misleading.
How Biograph Transforms Data Into a Personalized Plan
Most self-serve diagnostics offer numerical results but little in the way of interpretation or prioritization. A slightly high LDL, borderline low testosterone, or an elevated inflammation marker can all prompt confusion or anxiety when presented in isolation. But true insight comes from connecting the dots across systems.
30+
Exams in a single day for Black tier members
1,000+
Data points analyzed to generate your personalized risk and health profile
Biograph’s clinical model begins with deep diagnostics, generating over 1,000 data points from 20+ evaluations in the Core tier and 30+ in the Black tier. These assessments include blood panels, full-body MRI, VO2 max testing, DEXA scans, and more. The results are synthesized into a multidomain risk profile that integrates both chronic disease indicators and quality of life metrics.
Our clinical team organizes your results into five primary areas: cardiovascular disease, metabolic dysfunction, neurodegenerative disease, cancer risk, and quality-of-life indicators such as sleep quality, resilience, and functional fitness. From there, we review your complete health picture with you in one-on-one consultations, helping you prioritize the areas that matter most and translate insights into a personalized action plan. This approach ensures that every recommendation is grounded in clinical evidence and tailored to your goals, preferences, and capacity for change.
CASE STUDY
Making Health Data Actionable
A mid-40s Biograph member with a strong family history of cardiovascular disease came in for a comprehensive evaluation. On the surface, he appeared in excellent shape, with high cardiorespiratory fitness and above-average lean mass.
But deeper testing told a more complex story. Body composition scans revealed elevated visceral fat mass and a high fat mass index, both hidden markers of metabolic risk. Bloodwork showed fasting hyperglycemia, insulin resistance, and elevated LDL cholesterol and ApoB levels. Sleep assessments uncovered poor sleep quality, adding another layer of stress to his system.
Biograph’s multidisciplinary team provided targeted exercise and nutrition guidance to improve metabolic flexibility and reduce cardiovascular risk.
Exercise recommendations included Zone 2 aerobic training, resistance and stability work, and a structured weekly distribution of cardio zones.
Nutrition guidance focused on total daily calories, strategic food substitutions, meal timing, and defined targets for fiber, protein, and saturated fat.
After six months, follow-up assessments showed:
A 20-pound reduction in weight
A 20-30% reduction in LDL cholesterol, ApoB, and fasting insulin
Preserved lean muscle mass and marked improvements in total body fat index and visceral fat mass
Noticeably improved sleep quality
With the right diagnostic insights, targeted interventions like exercise and nutrition can dramatically reduce risks and transform long-term health outcomes – even in individuals who appear outwardly fit.
Five Key Tactics That Turn Data Into Health Outcomes
Data only becomes valuable when it leads to action. At Biograph, we structure personalized prevention and health optimization around five tactics.
Exercise
Nutrition
Sleep
Mental Health
Medications and Supplements
These domains are interdependent. Improving one often enhances the others. For example, better sleep can improve insulin sensitivity. Increased muscle mass can improve glucose disposal. Reduced inflammation can improve mood and cognitive performance.
Let’s look at how data informs each domain, and how targeted interventions create compounding benefits over time.
Exercise: Optimizing Strength, Stability, and Cardiorespiratory Fitness
Exercise is one of the most powerful tools in preventive medicine. At Biograph, we approach it through four pillars that support long-term health: Strength, Stability, Aerobic Capacity, and Metabolic Flexibility.
For every member, we assess baseline performance — using VO₂ max testing, grip strength, body composition, movement analysis, and a review of current exercise routines and goals — and design personalized recommendations to target the right mix of these pillars.
Strength: Resistance training can enhance insulin sensitivity, support joint health, and lower the risk of falls and frailty. Research shows that higher muscle mass and increased muscular strength are each independently associated with significantly lower all-cause mortality.
Stability: Addressing asymmetries and movement deficits increases movement efficiency, reduces injury risk, and supports overall physical performance.
Maximum Aerobic Capacity: VO₂ max, the gold standard for cardiorespiratory fitness, is a powerful predictor of long-term health. One major study found that individuals with elite cardiorespiratory fitness levels had up to a fivefold lower risk of all-cause mortality compared to those with low fitness.
Metabolic Flexibility: This reflects how efficiently the body uses fat as fuel at lower intensities. Properly integrating and balancing Zone 2 training with higher intensity exercise boosts fat oxidation and improves mitochondrial function — key for managing insulin resistance and enhancing recovery.
Together, improvements across these four areas enhance cardiovascular efficiency, metabolic control, and neuromuscular resilience. More importantly, they help preserve performance, autonomy, and quality of life into later decades.
Nutrition: Personalization Over Fads
Nutrition is foundational to metabolic and cardiovascular health, yet most public advice remains generalized. Studies have shown that individual responses to diet vary widely, underscoring the need for a personalized approach based on measurable biomarkers.
At Biograph, dietary planning is shaped by objective data. Comprehensive labs measure insulin sensitivity, lipid profiles, liver enzymes, micronutrient levels, and inflammatory markers. DEXA scans assess fat distribution and lean mass — critical factors influencing metabolic health and disease risk.
We also gather key personal inputs: eating patterns, nutrition goals, and any past challenges. These insights help ensure recommendations are not just biologically appropriate but also realistic and sustainable.
Biograph’s approach goes beyond generic dietary advice by aligning each member’s biology and behaviors with practical, evidence-based nutrition strategies. Depending on individual needs, this might mean a low-glycemic, high-fiber diet for elevated fasting insulin and low HDL cholesterol, increased protein intake to prevent sarcopenia, or targeted supplementation for vitamin deficiencies. We have also seen members successfully apply behavioral levers such as adjusting what they eat, how much they eat, or when they eat to reinforce these biological strategies and improve adherence.
Nutrition is not about following generalized rules. It is about applying the right strategies, tailored to each individual’s biology and needs, to drive real, lasting improvements.
Sleep and Mental Health: Essential Drivers of Long-Term Health
Sleep is one of the most underestimated pillars of health. Yet poor sleep quality is linked to increased risk of hypertension, obesity, insulin resistance, cognitive decline, and even cancer. Meta-analyses have confirmed that both short and disrupted sleep significantly increase the risk of all-cause mortality.
At Biograph, we assess sleep using validated surveys and at-home wearables that can detect disorders such as sleep apnea. If sleep apnea is identified, members are referred to our specialized sleep expert partners for additional consultation. Insomnia may benefit from referral for cognitive behavioral therapy for sleep, stress reduction protocols, and supplement support like magnesium, glycine, or melatonin under clinician guidance.
In parallel, we assess psychological resilience through validated tools that screen for depression and anxiety. Mental health is deeply interconnected with both sleep quality and long-term cardiovascular function. One large study found that depression is associated with a 52% increase in relative risk of all-cause mortality in older adults; another study found that chronic stress is associated with telomere shortening and accelerated biological aging.
At Biograph, these insights help identify opportunities for intervention and guide care planning across both psychological and physiological domains. We incorporate targeted support, including referrals for therapy, lifestyle counseling, and strategies that strengthen resilience, enhance cardiovascular and cognitive function, and sustain long-term vitality.
Medications and Supplements: Use Them When They Add Value
When risk is high or lifestyle change is not enough, medications and supplements can provide additional leverage. But the key is personalization.
For example, if a CT coronary angiography shows atherosclerosis, lipid-lowering therapy in combination with lifestyle intervention may be warranted. In randomized trials, statins have been shown to reduce major cardiac events by up to 20 percent in primary prevention populations. If insulin resistance is present, metformin is often considered in conjunction with lifestyle interventions. Beyond its role in improving metabolic health, metformin is being studied in the landmark TAME trial for its potential to modify age-related disease risk.
Supplement recommendations are similarly guided by diagnostics, targeting only confirmed deficiencies or therapeutic gaps, such as:
Vitamin D for low serum levels, especially in the context of bone or immune health
Vitamin B12 to address elevated serum homocysteine and long-term brain health
Omega-3s for high triglycerides or systemic inflammation
Magnesium to support muscle recovery and sleep quality
The goal is not to pile on supplements, but instead to strategically use interventions with proven benefit, guided by individualized data.
Conclusion: The Future of Preventive Health Is Personalized, Integrated, and Data-Driven
The future of prevention is not one-size-fits-all. It is personal, precise, and built to evolve. At Biograph, we turn diagnostics into action by creating data-informed strategies tailored to the individual, guided by experts, and measured by meaningful outcomes. This is not theoretical — we witness every day how personalized, data-driven plans drive meaningful, lasting improvements in health and longevity.
Turn Data Into Action
See how Biograph translates diagnostics into personalized, data-driven plans to extend your healthspan.
Written by Michael Doney
Executive Medical Director
Dr. Doney is Biograph’s Executive Medical Director, overseeing our entire clinical team. Prior to joining Biograph, he served as Director of Medical Affairs at Human Longevity and Group42 Healthcare, and spent 4 years at the US CDC as an Associate Division Director. He received his medical degree from the University of Cincinnati and completed his residency in emergency medicine at UC San Diego.
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